Rotavirus (RV) – RV1 (2-dose series); RV5 (3-dose series)
Recommended Age Range:
RV1: 2 and 4 months; RV5: 2, 4, and 6 months
Common Side Effects:
Irritability, mild diarrhea, vomiting
Research & Testing History:
RV5 (RotaTeq) trial with 70,000+ infants showed safety/efficacy; RV1 similar trials.
Use History:
Introducted mid-2000s
Trial Size:
RV5: 70,000; RV1: 63,000 infants
Years on Schedule:
~19 years
Known Safety Concerns:
Increases intussusception risk
Ingredients:
- RV1 (Rotarix): Live attenuated human rotavirus, sucrose, di-sodium adipate, Dulbecco’s Modified Eagle Medium (DMEM), fetal bovine serum, calcium carbonate, xanthan gum.
- RV5 (RotaTeq): Live reassortant rotaviruses, sucrose, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, polysorbate 80, cell culture media.